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Open research questions in Zoonotic diseases and public health

364 gap statements mined from Zoonotic diseases and public health papers in our 7.9M-paper local library, which holds 1,727 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

Choosing where to publish on Zoonotic diseases and public health? See the ranked Medicine journals.

What the literature leaves open

  • Retention of skilled professionals due to limited career pathways and professional growth opportunities. Dependence on external laboratories for bioinformatics analysis, compromising data sovereignty. Inconsistent implementation of data protection policies across African countries, hindering regional collaboration.

    The Case for Genomic Surveillance in Africa · 2025 · DOI

  • The lack of effective governance mechanisms and legal frameworks in One Health initiatives. The need for better multisectoral communication, collaboration, and capacity building in zoonoses, food hygiene, and antimicrobial resistance programs. The importance of considering the environmental sector in One Health initiatives.

    Assessment of One Health Initiatives from a Veterinary Public Health Approach in Latin America and the Caribbean · 2025 · DOI

  • The study notes the need to address the significant threats posed by zoonotic diseases to public health, economic development, and quality of life. The study highlights the importance of strengthening cross-sectoral cooperation to prevent and control zoonotic diseases.

    Epidemiological Characteristics and Trends of Zoonotic Diseases in China from 2015 to 2022 · 2025 · DOI

  • There is a need to strengthen cross-sectoral cooperation and develop region- and population-specific prevention and control strategies based on the 'One Health' concept. The study identifies the need to focus on areas with high incidence rates and among high-risk populations.

    Epidemiological Characteristics and Trends of Zoonotic Diseases in China from 2015 to 2022 · 2025 · DOI

  • Future efforts to reduce the risk of zoonotic spillover from animals to humans at high-risk interfaces should consider meaningful community engagement and participatory approaches from project initiation and throughout.

    Community Participatory Approach to Design, Test, and Implement Interventions That Reduce Risk of Bat-Borne Disease Spillover: A Case Study from Cambodia · 2025 · DOI

  • The paper identifies the need for a transdisciplinary approach to address complex health challenges. It highlights the importance of cross-sector collaboration and the need for sustainable funding for the One Health workforce. The paper also emphasizes the importance of education and workforce development in building a sustainable One Health strategy.

    One Health Landscape in Tennessee: Current Status, Challenges, and Priorities · 2025 · DOI

  • Soil invertebrates, such as earthworms and nematodes, may act as important reservoirs of bacterial pathogens, but their global distribution patterns and environmental drivers remain poorly understood.

    Global change influences the prevalence and diversity of gut bacterial pathogens in soil invertebrates · 2026 · DOI

  • Monitoring of companion animal zoonotic diseases in Canada is limited by the lack of a comprehensive companion animal health surveillance system, capable of integrating environmental and public health data.

    Companion animal health surveillance systems: An environmental scan · 2025 · DOI

  • It is crucial to implement focused educational initiatives and preventative measures to effectively tackle gaps in knowledge concerning zoonotic diseases and to avert potential infections.

    Knowledge, attitudes and practices regarding zoonotic diseases among cat and dog owners in Bangladesh · 2024 · DOI

  • Government departments must expand veterinary surveillance, diagnostic testing, and mobile clinic services in underserved rural communities. Government departments must strengthen interdepartmental collaboration through a One Health approach that links animal health, human health, and environmental management.

    Prevalence and risk factors of zoonotic diseases on the human-wildlife-livestock interface in eastern cape and KwaZulu-Natal provinces, South Africa · 2026 · DOI

  • There is a gap in the integration of animal and environmental components in One Health-related infectious disease studies. Most studies relied exclusively on human data.

    The use of artificial intelligence based modelling techniques in One Health-related infectious disease studies in Sub-Saharan Africa: a review · 2026 · DOI

  • Co-design methodologies involving communities, health workers, and policymakers for developing culturally relevant and operationally feasible AI tools for One Health infectious disease applications in SSA contexts have not been documented in the literature.

    The use of artificial intelligence based modelling techniques in One Health-related infectious disease studies in Sub-Saharan Africa: a review · 2026 · DOI

  • There is a lack of understanding of the role of rodents in One Health programs. The paper identifies a gap in the integration of rodent management into One Health frameworks.

    Putting Rodents at the Center of One Health Programs: A Narrative Synthesis · 2026 · DOI

  • Future research should focus on developing shared methodological principles for One Health measurement. Research should prioritize participatory and transparent design processes. Further studies should explore the application of the proposed principles in different contexts and settings.

    Issues and principles for legitimate and meaningful One Health monitoring · 2026 · DOI

  • There is a lack of a widely accepted method to assess and monitor the overall state of health across interconnected domains. Existing evaluation frameworks focus on implementation rather than outcomes. There is a need for clearer methodological guidance for One Health measurement.

    Issues and principles for legitimate and meaningful One Health monitoring · 2026 · DOI

  • Unequal access to healthcare services remains a major barrier in low-income and developing countries. Vaccine hesitancy refers to the reluctance or refusal to receive vaccines despite their availability. The continuous evolution of infectious agents presents scientific and logistical challenges.

    THE ROLE OF VACCINATION IN PREVENTING GLOBAL INFECTIOUS DISEASES · 2026 · DOI

  • Further study is needed to understand the complex relationships between biodiversity loss, habitat destruction, and emerging infectious diseases. Research is needed to develop effective strategies for preventing future pandemics through habitat protection and wildlife trade reform.

    Biodiversity Loss and the Rise of Emerging Infectious Diseases: An Ecological Analysis · 2026 · DOI

  • There is a gap in understanding how bats limit getting sick from viruses. Most of the research on bat immune responses to viruses has focused only on a handful of species.

    Do Bats Get Sick From the Viruses They Carry? · 2026 · DOI

  • Our study limited to a small geographical area within China and these SARS-CoV-2 zoonotic events are probably just the "tip of the iceberg.

    SARS‐CoV‐2 Reverse Zoonosis Among Cats in China: A One Health Investigation · 2024 · DOI

  • The study had to address the issue of limited access to health education and healthcare services among hill tribe people.

    Comparisons of Risk Behaviors and Factors Associated with Poor Knowledge and Attitudes Toward Zoonotic Infection Among Hill Tribe People in Northern Thailand · 2026 · DOI

  • Technological advances are expected to further improve vaccine development and distribution. Personalized vaccine approaches and novel delivery systems may increase the efficiency of future immunization programs.

    THE ROLE OF VACCINATION IN PREVENTING GLOBAL INFECTIOUS DISEASES · 2026 · DOI

  • The destruction of natural habitats is one of the most powerful drivers of emerging infectious diseases known to science. The link between biodiversity loss and zoonotic diseases is causal, mechanistic, and deeply alarming.

    Biodiversity Loss and the Rise of Emerging Infectious Diseases: An Ecological Analysis · 2026 · DOI

  • Focus on those factors that might allow pathogens to circumvent the probabilistic barriers to their emergence, - Further research on the evidence for simultaneous emergence in several…

    Will there be a warning for the next pandemic? · 2026 · DOI

  • Prioritizing future efforts based on propensity scores - Using DPU learning to quantify prediction uncertainty and research effort - Applying the GNN to other host-pathogen modelling…

    Predicting unknown mammalian viral hosts with Dynamic Positive–Unlabeled learning · 2026 · DOI

  • The study reveals gaps in knowledge and practices of risks regarding zoonotic diseases among pet owners in Bangladesh.

    Knowledge, attitudes and practices regarding zoonotic diseases among cat and dog owners in Bangladesh · 2024 · DOI

Most-cited papers in Zoonotic diseases and public health

Most recent work

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Open questions raised by papers listed on this page include: (1) Soil invertebrates, such as earthworms and nematodes, may act as important reservoirs of bacterial pathogens, but their global distribution patterns and environmental drivers remain poorly understood (“Global change influences the prevalence and diversity of gut bacterial…”, 2026); (2) There is a lack of understanding of the role of rodents in One Health programs (“Putting Rodents at the Center of One Health Programs: A Narrative Synthesis”, 2026); (3) Future research should focus on developing shared methodological principles for One Health measurement (“Issues and principles for legitimate and meaningful One Health monitoring”, 2026); (4) Further study is needed to understand the complex relationships between biodiversity loss, habitat destruction, and emerging infectious diseases (“Biodiversity Loss and the Rise of Emerging Infectious Diseases: An Ecological…”, 2026); (5) The lack of effective governance mechanisms and legal frameworks in One Health initiatives (“Assessment of One Health Initiatives from a Veterinary Public Health Approach…”, 2025). 364 gap statements have been mined from Zoonotic diseases and public health papers in our 7.9M-paper local library, which holds 1,727 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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