Open research questions in Zoonotic diseases and public health
142 unresolved questions extracted from the limitations and future-work sections of 856 Zoonotic diseases and public health papers in our library. Each links back to the study that raised it.
What the literature leaves open
The study identifies the challenge of overcoming cultural and religious beliefs that influence practices shaping zoonotic disease transmission. The study notes the difficulty of identifying and sampling actors in the livestock trade. The study highlights the need to address the lack of formal training and education among livestock traders and trekkers.
Knowledge, perceptions, and practices around zoonotic diseases among actors in the livestock trade in the Lake Victoria crescent ecosystem in East Africa · 2024 · DOIfurther studies can investigate the effectiveness of One Health approaches, - research can explore the impact of zoonotic diseases on livelihoods, - studies can examine the role of cultural and religious beliefs in shaping practices
Knowledge, perceptions, and practices around zoonotic diseases among actors in the livestock trade in the Lake Victoria crescent ecosystem in East Africa · 2024 · DOIImplementing and optimizing the framework for use across many One Health challenge areas
Abstract The continued emergence of challenges in human, animal, and environmental health (One Health sectors) requires public servants to make management and policy decisions about system-level ecological and sociological processes that are complex, poorly understood, and change over time.
Practitioner perspectives on informing decisions in One Health sectors with predictive models · 2025 · DOIDespite the severity of these threats, rodent-borne parasitic diseases remain underrecognized, particularly in low-resource settings where surveillance and control efforts are often limited.
The establishment of a US-based clinical trial network to improve the study and subsequent implementation of therapies and strategies to treat and prevent infections in immunocompromised individuals would address this gap in research infrastructure and jumpstart public and private investment.
A Network for Advancing Prevention and Treatment of Infections Among Immunocompromised Individuals · 2025 · DOIWhile most countries increased crop production and decreased food imports during the crisis, government economic support during the pandemic varied widely.
Field evidence of how these subclinical infections induce changes in movement behaviour is scarce in free-ranging animals, yet it may be crucial for zoonotic disease surveillance.
Sick without signs. Subclinical infections reduce local movements, alter habitat selection, and cause demographic shifts · 2024 · DOILimited awareness about zoonotic diseases among smallholder livestock farmers. Risky consumption behaviors, such as consuming raw animal products. Poor biosecurity practices, including direct contact with wildlife and hunting.
Prevalence and risk factors of zoonotic diseases on the human-wildlife-livestock interface in eastern cape and KwaZulu-Natal provinces, South Africa · 2026 · DOIThere is a lack of awareness about zoonotic diseases among smallholder livestock farmers in South Africa. The study highlights the need for integrated One Health strategies to address the challenges posed by zoonotic diseases.
Prevalence and risk factors of zoonotic diseases on the human-wildlife-livestock interface in eastern cape and KwaZulu-Natal provinces, South Africa · 2026 · DOIThere is a gap in the integration of animal and environmental components in One Health-related infectious disease studies. Most studies relied exclusively on human data.
The use of artificial intelligence based modelling techniques in One Health-related infectious disease studies in Sub-Saharan Africa: a review · 2026 · DOICo-design methodologies involving communities, health workers, and policymakers for developing culturally relevant and operationally feasible AI tools for One Health infectious disease applications in SSA contexts have not been documented in the literature.
The use of artificial intelligence based modelling techniques in One Health-related infectious disease studies in Sub-Saharan Africa: a review · 2026 · DOIThe study faced challenges in collecting data from participants living in remote areas. The study had to address the issue of limited access to health education and healthcare services among hill tribe people.
Comparisons of Risk Behaviors and Factors Associated with Poor Knowledge and Attitudes Toward Zoonotic Infection Among Hill Tribe People in Northern Thailand · 2026 · DOIThere is a lack of understanding of the behaviors and factors associated with poor knowledge and attitudes toward zoonotic infection among hill tribe people in northern Thailand. The study aims to fill this gap by providing an understanding of the behaviors and factors associated with poor knowledge and attitudes toward zoonotic infection among hill tribe people.
Comparisons of Risk Behaviors and Factors Associated with Poor Knowledge and Attitudes Toward Zoonotic Infection Among Hill Tribe People in Northern Thailand · 2026 · DOIThere is a lack of understanding of the role of rodents in One Health programs. The paper identifies a gap in the integration of rodent management into One Health frameworks.
Little is known about the impacts of pet husbandry practices on wildlife in protected landscapes of many African countries. The study aims to fill this knowledge gap.
Low level of awareness about zoonotic risks among cat owners. Insufficient application of preventive veterinary measures. Limited knowledge about the transmission of zoonoses.
Attitudes, knowledge and behavior of cat owners of importance for the control of zoonotic diseases · 2026 · DOIThere is a significant public health gap in the level of awareness, knowledge and attitudes of owners about the potential risks associated with cat ownership. Many owners are not sufficiently familiar with the concept and mechanisms of transmission of zoonoses.
Attitudes, knowledge and behavior of cat owners of importance for the control of zoonotic diseases · 2026 · DOIThe need for interdisciplinary contributions to ensure a healthier, safer, and more sustainable future. The importance of recognizing veterinarians' role in public health, food safety, and environmental sustainability.
Future research should focus on developing shared methodological principles for One Health measurement. Research should prioritize participatory and transparent design processes. Further studies should explore the application of the proposed principles in different contexts and settings.
There is a lack of a widely accepted method to assess and monitor the overall state of health across interconnected domains. Existing evaluation frameworks focus on implementation rather than outcomes. There is a need for clearer methodological guidance for One Health measurement.
Further studies on the pathogen shedding routes, - Investigation of the zoonotic potential of the detected viruses, - Surveillance of wildlife pathogens in other regions
Infectome Landscape of Rodents and Shrews in Guangdong Province Reveals Diverse Pathogens with Zoonotic Potential in Wildlife · 2026 · DOIMany studies have focused only on the diversity and genetic evolution of viruses from wildlife, while ignoring non-viral pathogens. There is a need for comprehensive infectome analysis of rodents and shrews to identify diverse pathogens with zoonotic potential.
Infectome Landscape of Rodents and Shrews in Guangdong Province Reveals Diverse Pathogens with Zoonotic Potential in Wildlife · 2026 · DOIUnequal access to healthcare services remains a major barrier in low-income and developing countries. Vaccine hesitancy refers to the reluctance or refusal to receive vaccines despite their availability. The continuous evolution of infectious agents presents scientific and logistical challenges.
Modern public health strategies emphasize strengthening immunization systems and improving vaccine accessibility. Technological advances are expected to further improve vaccine development and distribution. Personalized vaccine approaches and novel delivery systems may increase the efficiency of future immunization programs.
Most-cited papers in Zoonotic diseases and public health
- Global trends in emerging infectious diseases · Nature · 2008 · 6,719 citations
- Emerging Infectious Diseases of Wildlife-- Threats to Biodiversity and Human Health · Science · 2000 · 3,291 citations
- Syndemics and Public Health: Reconceptualizing Disease in Bio‐Social Context · Medical Anthropology Quarterly · 2003 · 919 citations
- Impact of recent and future climate change on vector‐borne diseases · Annals of the New York Academy of Sciences · 2018 · 762 citations
- Unhealthy Landscapes: Policy Recommendations on Land Use Change and Infectious Disease Emergence · Environmental Health Perspectives · 2004 · 749 citations
- Historical Prevalence of Infectious Diseases Within 230 Geopolitical Regions: A Tool for Investigating Origins of Culture · Journal of Cross-Cultural Psychology · 2009 · 349 citations
- Potential Influence of Climate Change on Vector-Borne and Zoonotic Diseases: A Review and Proposed Research Plan · Environmental Health Perspectives · 2010 · 322 citations
- EMERGING AND RE-EMERGING INFECTIOUS DISEASES: The Third Epidemiologic Transition · Annual Review of Anthropology · 1998 · 314 citations
- The Earth BioGenome Project 2020: Starting the clock · Proceedings of the National Academy of Sciences · 2022 · 303 citations
- The costs and benefits of primary prevention of zoonotic pandemics · Science Advances · 2022 · 272 citations
Most recent work
- Scaling Lassa Virus Dynamics within Anthropogenic Ecosystems (SCAPES) Study Protocol: a mixed-methods observational cohort study of humans, rodents, and landscapes in Nigeria. · Wellcome Open Research · 2026
- Small islands as system and scale to examine the One Health concept · BioScience · 2026
- Stochastic models indicate rapid smallpox spread and mass mortality of Indigenous Australians after colonial exposure · Nature Human Behaviour · 2026
- Leveraging Long‐Term Ecological Research Initiatives Into the One Health Synthesis · Ecology and Evolution · 2026
- Seven reasons why threatened species managers must consider genetic health · BioScience · 2026
- The Role of “One Health” in Pediatric Well-Being · The Journal of Pediatrics · 2026
- Viral RNA persistence and long-term consequences following acute infection with Risk Group 4 zoonotic viruses · Frontiers in Cellular and Infection Microbiology · 2026
- Participation of livestock farmers and community animal health workers in one health intervention to control zoonotic diseases in Rwanda: a qualitative study · BMC Infectious Diseases · 2026
- An agricultural perspective on One Health · Frontiers in Sustainable Food Systems · 2026
- Prevalence and risk factors of zoonotic diseases on the human-wildlife-livestock interface in eastern cape and KwaZulu-Natal provinces, South Africa · Frontiers in Veterinary Science · 2026
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